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Article

The activation peptide of coagulation factor XIII is vital for its expression and stability.

Journal of thrombosis and haemostasis : JTH - 1 Aug 2015

Handrkova H, Schroeder V, Kohler H P

Abstract excerpt

BACKGROUND: The human activation peptide of factor XIII (AP-FXIII) comprises the first 37 amino acids of the N-terminus and holds the FXIII in an inactive state. FXIII is activated either proteolytically by cleavage of AP-FXIII by thrombin, or non-proteolytically by high calcium concentrations. OBJECTIVE: To investigate the role of AP-FXIII in the expression and stability of FXIII. METHODS: We cloned 13 FXIII...

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Identifiers

PMID: 26083359
DOI: 10.1111/jth.13035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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