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Article

Genotyping single-nucleotide polymorphisms of human genes involved in organophosphate detoxification by high-resolution melting.

Analytical and bioanalytical chemistry - 1 Aug 2014

Kurdyukov Ivan, Rodionov Gennady, Radilov Andrey, Babakov Vladimir

Abstract excerpt

Paraoxonase-1 (PON1) and butyrylcholinesterase (BCHE) are natural bioscavengers of organophosphate acetylcholinesterase inhibitors in the human body, which can determine individual sensitivity to organophosphate toxicity. Interindividual differences in activity of PON1 (catalytic bioscavenger) and substrate specificity are strongly associated with the substitution of two amino acids: Leu/Met (L/M) at position 55...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24705954
DOI: 10.1007/s00216-014-7734-7

Genes

BCHE
PON1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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