Article
Beta2 adrenergic receptor (ADRβ2) haplotype pair (2/4) is associated with severe asthma.
PloS one - 1 Jan 2014
Chung Li Ping, Baltic Svetlana, Ferreira Manuel, Temple Suzanna, Waterer Grant, Thompson Philip J
Abstract excerpt
BACKGROUND: β2 adrenergic receptor (ADRβ2) polymorphisms including ADRβ2+46G>A have been reported to cause adverse outcomes in mild asthmatics. The extent to which ADRβ2 polymorphisms and in particular their haplotypes contribute to severe asthma is unknown. OBJECTIVE: To determine the association of ADRβ2 polymorphisms and haplotypes with asthma severity. METHODS: Caucasians (n = 2979) were genotyped for 11...
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