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Article

beta2-Adrenergic receptor haplotypes in mild, moderate and fatal/near fatal asthma.

American journal of respiratory and critical care medicine - 1 Sept 1998

Weir T D, Mallek N, Sandford A J, Bai T R, Awadh N, Fitzgerald J M, Cockcroft D, James A, Liggett S B, Paré P D

Abstract excerpt

Excess beta2-agonist use in asthmatics has been associated with increased mortality and morbidity. The mechanisms responsible for these observations are unknown. We hypothesized that polymorphisms of the beta2-adrenergic receptor (beta2AR) at amino acid positions 16, 27, and 164, which are known to alter receptor functions in vitro, may predispose asthmatics to fatal/near-fatal asthma and/or modify asthma...

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PMID: 9731005
DOI: 10.1164/ajrccm.158.3.9801035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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