Article
beta2-Adrenergic receptor haplotypes in mild, moderate and fatal/near fatal asthma.
American journal of respiratory and critical care medicine - 1 Sept 1998
Weir T D, Mallek N, Sandford A J, Bai T R, Awadh N, Fitzgerald J M, Cockcroft D, James A, Liggett S B, Paré P D
Abstract excerpt
Excess beta2-agonist use in asthmatics has been associated with increased mortality and morbidity. The mechanisms responsible for these observations are unknown. We hypothesized that polymorphisms of the beta2-adrenergic receptor (beta2AR) at amino acid positions 16, 27, and 164, which are known...
Topics
- Adrenergic beta-Agonists
- Adult
- Alleles
- Amino Acids
- Anti-Asthmatic Agents
- Asian People
- Asthma
- Black People
- Cause of Death
- DNA
- Down-Regulation
- Ethnicity
- Gene Frequency
- Genetic Variation
- Genotype
- Glutamine
- Glycine
- Haplotypes