Article
Beta2-adrenergic receptor polymorphisms are associated with asthma and COPD in adults.
Journal of human genetics - 1 Jan 2006
Matheson Melanie C, Ellis Justine A, Raven Joan, Johns David P, Walters E Haydn, Abramson Michael J
Abstract excerpt
The beta(2)-adrenergic receptor (beta(2)AR) is a transmembrane protein expressed by airway smooth muscle cells. In vitro studies have shown that polymorphisms at amino acid positions 16 and 27 alter receptor function. The aim of this study was to examine the associations between the beta ( 2 ) AR polymorphisms and risks of asthma, chronic obstructive pulmonary disease (COPD) and respiratory symptoms in a sample...
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