Article
Beta2-adrenoceptor polymorphisms and obstructive airway diseases: important issues of study design.
Clinical and experimental pharmacology & physiology - 1 Oct 2007
Yang Ian A, Ng Taria, Molenaar Peter, Fong Kwun M
Abstract excerpt
1. Asthma and chronic obstructive pulmonary disease (COPD) are chronic airway diseases characterized by airflow obstruction. The beta(2)-adrenoceptor mediates bronchodilatation in response to exogenous and endogenous beta-adrenoceptor agonists. 2. Single nucleotide polymorphisms in the beta(2)-adrenoceptor gene (ADRB2) cause amino acid changes (e.g. Arg16Gly, Gln27Glu) that potentially alter receptor function....
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