Article
Genetic variation of the beta(2)-adrenoceptor: its functional and clinical importance in bronchial asthma.
American journal of pharmacogenomics : genomics-related research in drug development and clinical practice - 1 Jan 2001
Taylor D R, Kennedy M A
Abstract excerpt
Asthma is a polygenic disease for which no clear genotype-phenotype relationships have emerged. In contrast, although not associated with the diagnosis of asthma per se, variant forms of the beta(2)-adrenoceptor (beta2-AR) gene (ADRB2) display functional effects that may be clinically relevant. Single nucleotide polymorphisms (SNPs) of ADBR2 are common and result in amino acid substitutions at positions 16, 27,...
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