ADRB2 haplotypes and asthma exacerbations in children and young adults: An individual participant data meta-analysis.

doi:10.1111/cea.13965

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Article

ADRB2 haplotypes and asthma exacerbations in children and young adults: An individual participant data meta-analysis.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Sept 2021

Karimi Leila, Vijverberg Susanne J, Engelkes Marjolein, Hernandez-Pacheco Natalia, Farzan Niloufar, Soares Patricia, Pino-Yanes Maria, Jorgensen Andrea L, Eng Celeste, Mukhopadhyay Somnath, Schieck Maximilian, Kabesch Michael, Burchard Esteban G, Chew Fook Tim, Sio Yang Yie, Potočnik Uroš, Gorenjak Mario, Hawcutt Daniel B, Palmer Colin N, Turner Steve, Janssens Hettie M, Maitland-van der Zee Anke H, Verhamme Katia M C

Abstract excerpt

BACKGROUND: The polymorphism Arg16 in β2 -adrenergic receptor (ADRB2) gene has been associated with an increased risk of exacerbations in asthmatic children treated with long-acting β2 -agonists (LABA). However, it remains unclear whether this increased risk is mainly attributed to this single variant or the combined effect of the haplotypes of polymorphisms at codons 16 and 27. OBJECTIVE: We assessed whether the...

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Identifiers

PMID: 34128573
DOI: 10.1111/cea.13965
PMCID: PMC8503671

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