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Article

Effect of ADRB2 polymorphisms on response to longacting beta2-agonist therapy: a pharmacogenetic analysis of two randomised studies.

Lancet (London, England) - 22 Dec 2007

Bleecker Eugene R, Postma Dirkje S, Lawrance Rachael M, Meyers Deborah A, Ambrose Helen J, Goldman Mitch

Abstract excerpt

BACKGROUND: New evidence has suggested that people with asthma who are homozygous for arginine at aminoacid 16 of the beta2-adrenergic receptor (ADRB2) might not benefit from longacting beta2-agonist therapy. We, therefore, investigated whether ADRB2 polymorphisms affect response to longacting beta2-agonists in combination with inhaled corticosteroids. METHODS: Asthmatics were stratified by ADRB2 genotype in two...

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Share to Adrenergic beta-Agonists
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Adrenergic, beta-2

Source

Identifiers

PMID: 18156033
DOI: 10.1016/S0140-6736(07)61906-0

Genes

ADRB2

Provenance

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Effect of ADRB2 polymorphisms on response to longacting beta2-agonist therapy: a pharmacogenetic analysis of two randomised studies.PMID 18156033Read ↗

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