Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IgA measurements in over 12 000 Swedish twins reveal sex differential heritability and regulatory locus near CD30L.

Human molecular genetics - 1 Aug 2014

Viktorin Alexander, Frankowiack Marcel, Padyukov Leonid, Chang Zheng, Melén Erik, Sääf Annika, Kull Inger, Klareskog Lars, Hammarström Lennart, Magnusson Patrik K E

Abstract excerpt

In a broad attempt to improve the understanding of the genetic regulation of serum IgA levels, the heritability was estimated in over 12 000 Swedish twins, and a genome-wide association study was conducted in a subsample of 9617. Using the classical twin model the heritability was found to be significantly larger among females (61%) compared with males (21%), while contribution from shared environment (20%) was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene-Environment Interaction
Share to Genetic Loci

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Human

Share to Immunoglobulin A

Share to Inheritance Patterns

Share to Sex Factors

Share to Sweden

Share to Twins, Monozygotic

Source

Open in PubMed Open full text

Identifiers

PMID: 24676358
DOI: 10.1093/hmg/ddu135
PMCID: PMC4082371

Genes

SASH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IgA measurements in over 12 000 Swedish twins reveal sex differential heritability and regulatory locus near CD30L.PMID 24676358Read ↗

The higher frequency of IgA deficiency among Swedish twins is not explained by HLA haplotypes.Semantic proximity Read ↗

IL5RA and TNFRSF6B gene variants are associated with sporadic IgA nephropathy.Semantic proximity Read ↗

High-density SNP mapping of the HLA region identifies multiple independent susceptibility loci associated with selective IgA deficiency.Semantic proximity Read ↗

Leveraging pleiotropy identifies common-variant associations with selective IgA deficiency.Semantic proximity Read ↗

Leveraging pleiotropy identifies common-variant associations with selective IgA deficiencySemantic proximity Read ↗

Genetic regulation of serum IgA levels and susceptibility to common immune, infectious, kidney, and cardio-metabolic traitsSemantic proximity Read ↗

Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease.Semantic proximity Read ↗

Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases.Semantic proximity Read ↗

Genome wide association identifies common variants at the SERPINA6/SERPINA1 locus influencing plasma cortisol and corticosteroid binding globulin.Semantic proximity Read ↗

Replication of association at the LPP and UBASH3A loci in a UK autoimmune Addison's disease cohort.Semantic proximity Read ↗

Parallel genotyping of 10,204 single nucleotide polymorphisms to screen for susceptible genes for IgA nephropathy.Semantic proximity Read ↗

Genome-Wide Analyses Suggest Mechanisms Involving Early B-Cell Development in Canine IgA Deficiency.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.