Article
Parallel genotyping of 10,204 single nucleotide polymorphisms to screen for susceptible genes for IgA nephropathy.
Annals of the Academy of Medicine, Singapore - 1 Oct 2009
Woo Keng Thye, Lau Yeow Kok, Wong Kok Seng, Zhao Yi, Chan Choong Meng
Abstract excerpt
INTRODUCTION: IgA nephritis (IgAN) is the most common glomerulonephritis worldwide. We aim to genotype SNPs (single nucleotide polymorphisms) genomewide in patients with IgAN to search for genetic clues to its aetiology. MATERIALS AND METHODS: Genotyping for 10,204 SNPs genomewide was done with the Gene Chip Human Mapping 10K Microarray (Affymetrix). Twenty-eight patients with IgAN and 30 normal subjects were...
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