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Article

Genome-Wide Analyses Suggest Mechanisms Involving Early B-Cell Development in Canine IgA Deficiency.

PloS one - 1 Jan 2015

Olsson Mia, Tengvall Katarina, Frankowiack Marcel, Kierczak Marcin, Bergvall Kerstin, Axelsson Erik, Tintle Linda, Marti Eliane, Roosje Petra, Leeb Tosso, Hedhammar Åke, Hammarström Lennart, Lindblad-Toh Kerstin

Abstract excerpt

Immunoglobulin A deficiency (IgAD) is the most common primary immune deficiency disorder in both humans and dogs, characterized by recurrent mucosal tract infections and a predisposition for allergic and other immune mediated diseases. In several dog breeds, low IgA levels have been observed at a high frequency and with a clinical resemblance to human IgAD. In this study, we used genome-wide association studies...

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Source

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Identifiers

PMID: 26225558
DOI: 10.1371/journal.pone.0133844
PMCID: PMC4520476

Genes

KIRREL3
SERPINA9
SLIT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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