Article
Genome wide association identifies common variants at the SERPINA6/SERPINA1 locus influencing plasma cortisol and corticosteroid binding globulin.
PLoS genetics - 1 Jul 2014
Bolton Jennifer L, Hayward Caroline, Direk Nese, Lewis John G, Hammond Geoffrey L, Hill Lesley A, Anderson Anna, Huffman Jennifer, Wilson James F, Campbell Harry, Rudan Igor, Wright Alan, Hastie Nicholas, Wild Sarah H, Velders Fleur P, Hofman Albert, Uitterlinden Andre G, Lahti Jari, Räikkönen Katri, Kajantie Eero, Widen Elisabeth, Palotie Aarno, Eriksson Johan G, Kaakinen Marika, Järvelin Marjo-Riitta, Timpson Nicholas J, Davey Smith George, Ring Susan M, Evans David M, St Pourcain Beate, Tanaka Toshiko, Milaneschi Yuri, Bandinelli Stefania, Ferrucci Luigi, van der Harst Pim, Rosmalen Judith G M, Bakker Stephen J L, Verweij Niek, Dullaart Robin P F, Mahajan Anubha, Lindgren Cecilia M, Morris Andrew, Lind Lars, Ingelsson Erik, Anderson Laura N, Pennell Craig E, Lye Stephen J, Matthews Stephen G, Eriksson Joel, Mellstrom Dan, Ohlsson Claes, Price Jackie F, Strachan Mark W J, Reynolds Rebecca M, Tiemeier Henning, Walker Brian R
Abstract excerpt
Variation in plasma levels of cortisol, an essential hormone in the stress response, is associated in population-based studies with cardio-metabolic, inflammatory and neuro-cognitive traits and diseases. Heritability of plasma cortisol is estimated at 30-60% but no common genetic contribution has been identified. The CORtisol NETwork (CORNET) consortium undertook genome wide association meta-analysis for plasma...
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