Article
Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease.
Journal of human genetics - 1 Jun 2021
Crawford Andrew A, Bankier Sean, Altmaier Elisabeth, Barnes Catriona L K, Clark David W, Ermel Raili, Friedrich Nele, van der Harst Pim, Joshi Peter K, Karhunen Ville, Lahti Jari, Mahajan Anubha, Mangino Massimo, Nethander Maria, Neumann Alexander, Pietzner Maik, Sukhavasi Katyayani, Wang Carol A, Bakker Stephan J L, Bjorkegren Johan L M, Campbell Harry, Eriksson Johan, Gieger Christian, Hayward Caroline, Jarvelin Marjo-Riitta, McLachlan Stela, Morris Andrew P, Ohlsson Claes, Pennell Craig E, Price Jackie, Rudan Igor, Ruusalepp Arno, Spector Tim, Tiemeier Henning, Völzke Henry, Wilson James F, Michoel Tom, Timpson Nicolas J, Smith George Davey, Walker Brian R
Abstract excerpt
The stress hormone cortisol modulates fuel metabolism, cardiovascular homoeostasis, mood, inflammation and cognition. The CORtisol NETwork (CORNET) consortium previously identified a single locus associated with morning plasma cortisol. Identifying additional genetic variants that explain more of the variance in cortisol could provide new insights into cortisol biology and provide statistical power to test the...
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