Article
ATR suppresses endogenous DNA damage and allows completion of homologous recombination repair.
PloS one - 1 Jan 2014
Brown Adam D, Sager Brian W, Gorthi Aparna, Tonapi Sonal S, Brown Eric J, Bishop Alexander J R
Abstract excerpt
DNA replication fork stalling or collapse that arises from endogenous damage poses a serious threat to genome stability, but cells invoke an intricate signaling cascade referred to as the DNA damage response (DDR) to prevent such damage. The gene product ataxia telangiectasia and Rad3-related (ATR) responds primarily to replication stress by regulating cell cycle checkpoint control, yet it's role in DNA repair,...
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