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Article

ATR disruption leads to chromosomal fragmentation and early embryonic lethality.

Genes & development - 15 Feb 2000

Brown E J, Baltimore D

Abstract excerpt

Although a small decrease in survival and increase in tumor incidence was observed in ATR(+/-) mice, ATR(-/-) embryos die early in development, subsequent to the blastocyst stage and prior to 7.5 days p.c. In culture, ATR(-/-) blastocysts cells continue to cycle into mitosis for 2 days but subseq...

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Source

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Identifiers

PMID: 10691732
PMCID: PMC316378

Genes

ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-10691732-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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