Article
Numerical analysis of intensity signals resulting from genotyping pooled DNA samples in beef cattle and broiler chicken.
Journal of animal science - 1 May 2014
Reverter A, Henshall J M, McCulloch R, Sasazaki S, Hawken R, Lehnert S A
Abstract excerpt
Pooled genomic DNA has been proposed as a cost-effective approach in genomewide association studies (GWAS). However, algorithms for genotype calling of biallelic SNP are not adequate with pooled DNA samples because they assume the presence of 2 fluorescent signals, 1 for each allele, and operate under the expectation that at most 2 copies of the variant allele can be found for any given SNP and DNA sample. We...
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