Article
A genome-wide study of preferential amplification/hybridization in microarray-based pooled DNA experiments.
Nucleic acids research - 1 Jan 2006
Yang H-C, Liang Y-J, Huang M-C, Li L-H, Lin C-H, Wu J-Y, Chen Y-T, Fann C S J
Abstract excerpt
Microarray-based pooled DNA methods overcome the cost bottleneck of simultaneously genotyping more than 100 000 markers for numerous study individuals. The success of such methods relies on the proper adjustment of preferential amplification/hybridization to ensure accurate and reliable allele frequency estimation. We performed a hybridization-based genome-wide single nucleotide polymorphisms (SNPs) genotyping...
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