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Article

Analysis of pooled DNA samples on high density arrays without prior knowledge of differential hybridization rates.

Nucleic acids research - 20 Apr 2006

Macgregor Stuart, Visscher Peter M, Montgomery Grant

Abstract excerpt

Array based DNA pooling techniques facilitate genome-wide scale genotyping of large samples. We describe a structured analysis method for pooled data using internal replication information in large scale genotyping sets. The method takes advantage of information from single nucleotide polymorphisms (SNPs) typed in parallel on a high density array to construct a test statistic with desirable statistical...

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Identifiers

PMID: 16627870
DOI: 10.1093/nar/gkl136
PMCID: PMC1440945

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