Article
Machine learning approach for pooled DNA sample calibration.
BMC bioinformatics - 9 Jul 2015
Hellicar Andrew D, Rahman Ashfaqur, Smith Daniel V, Henshall John M
Abstract excerpt
BACKGROUND: Despite ongoing reduction in genotyping costs, genomic studies involving large numbers of species with low economic value (such as Black Tiger prawns) remain cost prohibitive. In this scenario DNA pooling is an attractive option to reduce genotyping costs. However, genotyping of pooled samples comprising DNA from many individuals is challenging due to the presence of errors that exceed the allele...
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