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Article

Quantitative determination of allele frequency in pooled DNA by using sequencing method.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences - 1 Mar 2011

Cao Peng, Wang Qiu-Jun, Zhu Xu-Ting, Zhou Huan, Li Rui, Wang Wei-Peng

Abstract excerpt

Quantitative determination of the allele frequency of single-nucleotide polymorphism (SNP) in pooled DNA samples is a promising approach to clarify the relationships between SNPs and diseases. Here, we present such a simple, accurate, and inexpensive method for quantitative determining the allele frequency in pooled DNA samples. Three steps of DNA pooling, PCR amplification and sequencing are involved in this...

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PMID: 21277843
DOI: 10.1016/j.jchromb.2011.01.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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