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Article

p57 regulates T-cell development and prevents lymphomagenesis by balancing p53 activity and pre-TCR signaling.

Blood - 29 May 2014

Matsumoto Akinobu, Takeishi Shoichiro, Nakayama Keiichi I

Abstract excerpt

T cells are key components of the immune system, playing a central role in cell-mediated immunity. The sequential differentiation of T cells is associated with strict regulation of the cell cycle at each developmental stage. A balance between p53 activity and pre-T cell receptor (TCR) signaling regulates proliferation and differentiation decisions made by these cells. The relation between maintenance of this...

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Identifiers

PMID: 24652995
DOI: 10.1182/blood-2013-10-532390

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