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Article

DNA damage-induced cellular senescence is sufficient to suppress tumorigenesis: a mouse model.

The Journal of experimental medicine - 11 Jun 2007

Van Nguyen Thang, Puebla-Osorio Nahum, Pang Hui, Dujka Melanie E, Zhu Chengming

Abstract excerpt

Tumor suppressor p53-dependent apoptosis is critical in suppressing tumorigenesis. Previously, we reported that DNA double-strand breaks (DSBs) at the V(D)J recombination loci induced genomic instability in the developing lymphocytes of nonhomologous end-joining (NHEJ)-deficient, p53-deficient mice, which led to rapid lymphomagenesis. To test the ability of p53-dependent cell cycle arrest to suppress...

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Identifiers

PMID: 17535972
DOI: 10.1084/jem.20062453
PMCID: PMC2118600

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Source receipt: pubmed, retrieved 7 Sept 2026.

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