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Article

The role of p53 in suppression of KSHV cyclin-induced lymphomagenesis.

Cancer research - 15 Jan 2004

Verschuren Emmy W, Hodgson J Graeme, Gray Joe W, Kogan Scott, Jones Nic, Evan Gerard I

Abstract excerpt

Kaposi's sarcoma-associated herpesvirus (KSHV) encodes a cyclin D homolog, K cyclin, that is thought to promote viral oncogenesis. However, expression of K cyclin in cultured cells not only triggers cell cycle progression but also engages the p53 tumor suppressor pathway, which probably restricts the oncogenic potential of K cyclin. Therefore, to assess the tumorigenic properties of K cyclin in vivo, we...

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Source

Identifiers

PMID: 14744772
DOI: 10.1158/0008-5472.can-03-1863

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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