Article
Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis.
The Journal of experimental medicine - 26 Nov 2007
Onoyama Ichiro, Tsunematsu Ryosuke, Matsumoto Akinobu, Kimura Taichi, de Alborán Ignacio Moreno, Nakayama Keiko, Nakayama Keiichi I
Abstract excerpt
Cell proliferation is strictly controlled during differentiation. In T cell development, the cell cycle is normally arrested at the CD4(+)CD8(+) stage, but the mechanism underlying such differentiation-specific exit from the cell cycle has been unclear. Fbxw7 (also known as Fbw7, Sel-10, hCdc4, or hAgo), an F-box protein subunit of an SCF-type ubiquitin ligase complex, induces the degradation of positive...
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