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Coordinate Regulation of Lipid Metabolism by Novel Nuclear Receptor Partnerships

12 Apr 2012

Abstract excerpt

Mammalian nuclear receptors broadly influence metabolic fitness and serve as popular targets for developing drugs to treat cardiovascular disease, obesity, and diabetes. However, the molecular mechanisms and regulatory pathways that govern lipid metabolism remain poorly understood. We previously found that the Caenorhabditis elegans nuclear hormone receptor NHR-49 regulates multiple genes in the fatty acid...

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PMID: 22511885
DOI: 10.1371/journal.pgen.1002645

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