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Article

Nuclear receptors NHR-49 and NHR-79 promote peroxisome proliferation to compensate for aldehyde dehydrogenase deficiency in C. elegans.

PLoS genetics - 1 Jul 2021

Zeng Lidan, Li Xuesong, Preusch Christopher B, He Gary J, Xu Ningyi, Cheung Tom H, Qu Jianan, Mak Ho Yi

Abstract excerpt

The intracellular level of fatty aldehydes is tightly regulated by aldehyde dehydrogenases to minimize the formation of toxic lipid and protein adducts. Importantly, the dysregulation of aldehyde dehydrogenases has been implicated in neurologic disorder and cancer in humans. However, cellular responses to unresolved, elevated fatty aldehyde levels are poorly understood. Here, we report that ALH-4 is a C. elegans...

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Identifiers

PMID: 34237064
DOI: 10.1371/journal.pgen.1009635
PMCID: PMC8291716

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