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Article

The nuclear hormone receptor NHR-86 controls anti-pathogen responses in C. elegans.

PLoS genetics - 1 Jan 2019

Peterson Nicholas D, Cheesman Hilary K, Liu Pengpeng, Anderson Sarah M, Foster Kyle J, Chhaya Richa, Perrat Paola, Thekkiniath Jose, Yang Qiyuan, Haynes Cole M, Pukkila-Worley Read

Abstract excerpt

Nuclear hormone receptors (NHRs) are ligand-gated transcription factors that control adaptive host responses following recognition of specific endogenous or exogenous ligands. Although NHRs have expanded dramatically in C. elegans compared to other metazoans, the biological function of only a few of these genes has been characterized in detail. Here, we demonstrate that an NHR can activate an anti-pathogen...

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Identifiers

PMID: 30668573
DOI: 10.1371/journal.pgen.1007935
PMCID: PMC6358101

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