Article

Transcriptional suppression of sphingolipid catabolism controls pathogen resistance in <i>C. elegans</i>

2023-08-11

Abstract excerpt

<h4>ABSTRACT</h4> Sphingolipids are required for diverse biological functions and are degraded by specific catabolic enzymes. However, the mechanisms that regulate sphingolipid catabolism are not known. Here we characterize a transcriptional axis that regulates sphingolipid breakdown to control resistance against bacterial infection. From an RNAi screen for transcriptional regulators of pathogen resistance in the...

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Literature Corpus work: 31a80566-238c-5027-be30-96aedbf00b78
DOI: 10.1101/2023.08.10.552843

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