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Article

Transgenic expression of constitutively active RAC1 disrupts mouse rod morphogenesis.

Investigative ophthalmology & visual science - 25 Apr 2014

Song Hongman, Bush Ronald A, Vijayasarathy Camasamudram, Fariss Robert N, Kjellstrom Sten, Sieving Paul A

Abstract excerpt

PURPOSE: Dominant-active RAC1 rescues photoreceptor structure in Drosophila rhodopsin-null mutants, indicating an important role in morphogenesis. This report assesses the morphogenetic effect of activated RAC1 during mammalian rod photoreceptor development using transgenic mice that express constitutively active (CA) RAC1. METHODS: Transgenic mice were generated by expressing CA RAC1 under control of the...

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Source

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Identifiers

PMID: 24651551
DOI: 10.1167/iovs.13-13649
PMCID: PMC4001786

Genes

RAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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