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Article

Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival.

Developmental biology - 1 Dec 2011

Maddala Rupalatha, Chauhan Bharesh K, Walker Christopher, Zheng Yi, Robinson Michael L, Lang Richard A, Rao Ponugoti V

Abstract excerpt

Morphogenesis and shape of the ocular lens depend on epithelial cell elongation and differentiation into fiber cells, followed by the symmetric and compact organization of fiber cells within an enclosed extracellular matrix-enriched elastic capsule. The cellular mechanisms orchestrating these different events however, remain obscure. We investigated the role of the Rac1 GTPase in these processes by targeted...

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Identifiers

PMID: 21945075
DOI: 10.1016/j.ydbio.2011.09.004
PMCID: PMC3215831

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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