Article
Stable rhodopsin/arrestin complex leads to retinal degeneration in a transgenic mouse model of autosomal dominant retinitis pigmentosa.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Nov 2006
Chen Jiayan, Shi Guang, Concepcion Francis A, Xie Guifu, Oprian Daniel, Chen Jeannie
Abstract excerpt
Over 100 rhodopsin mutation alleles have been associated with autosomal dominant retinitis pigmentosa (ADRP). These mutations appear to cause photoreceptor cell death through diverse molecular mechanisms. We show that K296E, a rhodopsin mutation associated with ADRP, forms a stable complex with arrestin that is toxic to mouse rod photoreceptors. This cell death pathway appears to be conserved from flies to...
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