Article
Rac function and regulation during Drosophila development.
Nature - 28 Mar 2002
Hakeda-Suzuki Satoko, Ng Julian, Tzu Julia, Dietzl Georg, Sun Yan, Harms Matthew, Nardine Tim, Luo Liqun, Dickson Barry J
Abstract excerpt
Rac GTPases regulate the actin cytoskeleton to control changes in cell shape. To date, the analysis of Rac function during development has relied heavily on the use of dominant mutant isoforms. Here, we use loss-of-function mutations to show that the three Drosophila Rac genes, Rac1, Rac2 and Mtl, have overlapping functions in the control of epithelial morphogenesis, myoblast fusion, and axon growth and guidance....
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