Article
Rescue of photoreceptor degeneration in rhodopsin-null Drosophila mutants by activated Rac1.
Science (New York, N.Y.) - 8 Dec 2000
Chang H Y, Ready D F
Abstract excerpt
Rhodopsin is essential for photoreceptor morphogenesis; photoreceptors lacking rhodopsin degenerate in humans, mice, and Drosophila. Here we report that transgenic expression of a dominant-active Drosophila Rho guanosine triphosphatase, Drac1, rescued photoreceptor morphogenesis in rhodopsin-null mutants; expression of dominant-negative Drac1 resulted in a phenotype similar to that seen in rhodopsin-null mutants....
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