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Article

Arap1 Deficiency Causes Photoreceptor Degeneration in Mice.

Investigative ophthalmology & visual science - 1 Mar 2017

Moshiri Ala, Humpal Devin, Leonard Brian C, Imai Denise M, Tham Addy, Bower Lynette, Clary Dave, Glaser Thomas M, Lloyd K C Kent, Murphy Christopher J

Abstract excerpt

Purpose: Small guanosine triphosphatase (GTPase) ADP-ribosylation factors (Arfs) regulate membrane traffic and actin reorganization under the control of GTPase-activating proteins (GAPs). Arap1 is an Arf-directed GAP that inhibits the trafficking of epidermal growth factor receptor (EGFR) to the early endosome, but the diversity of its functions is incompletely understood. The aim of this study was to determine...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunohistochemistry

Share to Mice, Knockout

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Share to Photoreceptor Cells, Vertebrate

Share to Retinal Degeneration

Share to Tomography, Optical Coherence

Source

Open in PubMed Open full text

Identifiers

PMID: 28324111
DOI: 10.1167/iovs.16-20062
PMCID: PMC5361582

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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