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Article

Altered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active rac1.

The Journal of clinical investigation - 1 Apr 2000

Sussman M A, Welch S, Walker A, Klevitsky R, Hewett T E, Price R L, Schaefer E, Yager K

Abstract excerpt

The ras family of small GTP-binding proteins exerts powerful effects upon cell structure and function. One member of this family, rac, induces actin cytoskeletal reorganization in nonmuscle cells and hypertrophic changes in cultured cardiomyocytes. To examine the effect of rac1 activation upon cardiac structure and function, transgenic mice were created that express constitutively activated rac1 specifically in...

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Share to Cardiomyopathy, Dilated
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10749567
DOI: 10.1172/JCI8497
PMCID: PMC377478

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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