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Article

NOS1 Methylation and Carotid Artery Intima-Media Thickness in Children

13 Mar 2014

Abstract excerpt

BACKGROUND: Nitric oxide (NO) plays an important role in cardiovascular health by maintaining and regulating vascular tone and blood flow. Epigenetic regulation of NO synthase (NOS), the genes responsible for NO production, may affect cardiovascular disease, including the development of atherosclerosis in children. METHODS AND RESULTS: We measured percentage DNA methylation using bisulfite conversion and...

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PMID: 24622112
DOI: 10.1161/circgenetics.113.000320

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