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DNA Methylation in the Arginase–Nitric Oxide Synthase Pathway Is Associated with Exhaled Nitric Oxide in Children with Asthma

22 Apr 2011

Abstract excerpt

RATIONALE: Genetic variation in arginase (ARG) and nitric oxide synthase (NOS) has been associated with exhaled nitric oxide (FeNO) levels in children. Little is known about whether epigenetic variation in these genes modulates FeNO. OBJECTIVES: To evaluate whether DNA methylation in ARG and NOS genes is associated with FeNO. METHODS: A subset of 940 participants in the Children's Health Study were selected for...

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PMID: 21512169
DOI: 10.1164/rccm.201012-2029oc

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