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Article

Genetic variations in nitric oxide synthase and arginase influence exhaled nitric oxide levels in children.

Allergy - 1 Mar 2011

Salam M T, Bastain T M, Rappaport E B, Islam T, Berhane K, Gauderman W J, Gilliland F D

Abstract excerpt

BACKGROUND: Exhaled nitric oxide (FeNO) is a biomarker of airway inflammation. In the nitric oxide (NO) synthesis pathway, nitric oxide synthases (encoded by NOS1, NOS2A, and NOS3) and arginases (encoded by ARG1 and ARG2) compete for L-arginine. Although FeNO levels are higher in children with asthma/allergy, influence of these conditions on the relationships between variations in these genes and FeNO remains...

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Source

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Identifiers

PMID: 21039601
DOI: 10.1111/j.1398-9995.2010.02492.x
PMCID: PMC3058253

Genes

ARG2
ARG1
NOS1
NOS3

Provenance

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