Particulate Matter, DNA Methylation in Nitric Oxide Synthase, and Childhood Respiratory Disease

Abstract excerpt

BACKGROUND: Air pollutants have been associated with childhood asthma and wheeze. Epigenetic regulation of nitric oxide synthase--the gene responsible for nitric oxide production--may be affected by air pollutants and contribute to the pathogenesis of asthma and wheeze. OBJECTIVE: Our goal was to investigate the association between air pollutants, DNA methylation, and respiratory outcomes in children. METHODS:...

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