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Article

Genetic variance in nitric oxide synthase and endothelin genes among children with and without endothelial dysfunction.

Journal of translational medicine - 25 Sept 2013

Chatsuriyawong Siriporn, Gozal David, Kheirandish-Gozal Leila, Bhattacharjee Rakesh, Khalyfa Ahamed A, Wang Yang, Hakonarson Hakon, Keating Brendan, Sukhumsirichart Wasana, Khalyfa Abdelnaby

Abstract excerpt

BACKGROUND: The presence of endothelial dysfunction (ED) constitutes an early risk factor for cardiovascular disease (CVD) in children. Nitric oxide (NO) and endothelin (EDN) are generated in endothelial cells and are critical regulators of vascular function, with ED resulting from an imbalance between these two molecules. We hypothesized that genetic variants in NO synthase and EDN isoforms and its receptors...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24063765
DOI: 10.1186/1479-5876-11-227
PMCID: PMC3849009

Genes

EDN1
NOS1
EDNRA
EDNRB
EDN2
EDN3
NOS2
NOS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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