Article
Targeted next-generation sequencing and fine linkage disequilibrium mapping reveals association of PNPLA3 and PARVB with the severity of nonalcoholic fatty liver disease.
Journal of human genetics - 1 May 2014
Kitamoto Takuya, Kitamoto Aya, Yoneda Masato, Hyogo Hideyuki, Ochi Hidenori, Mizusawa Seiho, Ueno Takato, Nakao Kazuwa, Sekine Akihiro, Chayama Kazuaki, Nakajima Atsushi, Hotta Kikuko
Abstract excerpt
The genomic regions containing PNPLA3, SAMM50 and PARVB are susceptibility loci for the development and progression of nonalcoholic fatty liver disease (NAFLD). In order to search for all common variations in this region, we amplified the genomic DNA of 28 NAFLD patients by long-range PCR, covering the entire susceptibility region and sequenced the DNA using indexed multiplex next-generation sequencing. We found...
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