Article
Screening for rare variants in the PNPLA3 gene in obese liver biopsy patients.
Clinics and research in hepatology and gastroenterology - 1 Dec 2016
Zegers Doreen, Verrijken An, Francque Sven, de Freitas Fenna, Beckers Sigri, Aerts Evi, Ruppert Martin, Hubens Guy, Michielsen Peter, Van Hul Wim, Van Gaal Luc F
Abstract excerpt
BACKGROUND: Previous research has clearly implicated the PNPLA3 gene in the etiology of nonalcoholic fatty liver disease as a polymorphism in the gene was found to be robustly associated to the disease. However, data on the involvement of rare PNPLA3 variants in the development of nonalcoholic fatty liver disease (NAFLD) is currently limited. Therefore, we performed an extensive mutation analysis study on a...
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