Article
Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan.
Human genetics - 1 Jul 2013
Kitamoto Takuya, Kitamoto Aya, Yoneda Masato, Hyogo Hideyuki, Ochi Hidenori, Nakamura Takahiro, Teranishi Hajime, Mizusawa Seiho, Ueno Takato, Chayama Kazuaki, Nakajima Atsushi, Nakao Kazuwa, Sekine Akihiro, Hotta Kikuko
Abstract excerpt
We examined the genetic background of nonalcoholic fatty liver disease (NAFLD) in the Japanese population, by performing a genome-wide association study (GWAS). For GWAS, 392 Japanese NAFLD subjects and 934 control individuals were analyzed. For replication studies, 172 NAFLD and 1,012 control subjects were monitored. After quality control, 261,540 single-nucleotide polymorphisms (SNPs) in autosomal chromosomes...
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