Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeted-bisulfite sequence analysis of the methylation of CpG islands in genes encoding PNPLA3, SAMM50, and PARVB of patients with non-alcoholic fatty liver disease.

Journal of hepatology - 1 Aug 2015

Kitamoto Takuya, Kitamoto Aya, Ogawa Yuji, Honda Yasushi, Imajo Kento, Saito Satoru, Yoneda Masato, Nakamura Takahiro, Nakajima Atsushi, Hotta Kikuko

Abstract excerpt

BACKGROUND & AIMS: The pathogenesis of non-alcoholic fatty liver disease (NAFLD) is affected by epigenetic factors as well as by genetic variation. METHODS: We performed targeted-bisulfite sequencing to determine the levels of DNA methylation of 4 CpG islands (CpG99, CpG71, CpG26, and CpG101) in the regulatory regions of PNPLA3, SAMM50, PARVB variant 1, and PARVB variant 2, respectively. We compared the levels of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actinin
Share to CpG Islands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Lipase

Share to Membrane Proteins

Share to Non-alcoholic Fatty Liver Disease

Share to Phosphoproteins

Source

Identifiers

PMID: 25776890
DOI: 10.1016/j.jhep.2015.02.049

Genes

PNPLA3
PARVB
SAMM50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted-bisulfite sequence analysis of the methylation of CpG islands in genes encoding PNPLA3, SAMM50, and PARVB of patients with non-alcoholic fatty liver disease.PMID 25776890Read ↗

Targeted next-generation sequencing and fine linkage disequilibrium mapping reveals association of PNPLA3 and PARVB with the severity of nonalcoholic fatty liver disease.Semantic proximity Read ↗

Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan.Semantic proximity Read ↗

Association Between Active DNA Demethylation and Liver Fibrosis in Individuals with Metabolic‐ Associated Steatotic Liver Disease (MASLD)Semantic proximity Read ↗

Epigenome-Wide Association Study Identifies Methylation Sites Associated With Liver Enzymes and Hepatic Steatosis.Semantic proximity Read ↗

Differentially methylated loci in NAFLD cirrhosis are associated with key signaling pathwaysSemantic proximity Read ↗

Association Between Active DNA Demethylation and Liver Fibrosis in Individuals with Metabolic-Associated Steatotic Liver Disease (MASLD)Semantic proximity Read ↗

Differential DNA methylation of genes involved in fibrosis progression in non-alcoholic fatty liver disease and alcoholic liver diseaseSemantic proximity Read ↗

DNA methylome analysis reveals epigenetic alteration of complement genes in advanced metabolic dysfunction-associated steatotic liver diseaseSemantic proximity Read ↗

Whole-genome DNA methylation and gene expression profiling in the livers of mice with nonalcoholic steatohepatitisSemantic proximity Read ↗

Global analysis of DNA methylation in early-stage liver fibrosisSemantic proximity Read ↗

Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in miceSemantic proximity Read ↗

Differential DNA methylation and changing cell-type proportions as fibrotic stage progresses in NAFLDSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.