Article
GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network.
BMC medicine - 17 Jul 2019
Namjou Bahram, Lingren Todd, Huang Yongbo, Parameswaran Sreeja, Cobb Beth L, Stanaway Ian B, Connolly John J, Mentch Frank D, Benoit Barbara, Niu Xinnan, Wei Wei-Qi, Carroll Robert J, Pacheco Jennifer A, Harley Isaac T W, Divanovic Senad, Carrell David S, Larson Eric B, Carey David J, Verma Shefali, Ritchie Marylyn D, Gharavi Ali G, Murphy Shawn, Williams Marc S, Crosslin David R, Jarvik Gail P, Kullo Iftikhar J, Hakonarson Hakon, Li Rongling, Xanthakos Stavra A, Harley John B
Abstract excerpt
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver illness with a genetically heterogeneous background that can be accompanied by considerable morbidity and attendant health care costs. The pathogenesis and progression of NAFLD is complex with many unanswered questions. We conducted genome-wide association studies (GWASs) using both adult and pediatric participants from the Electronic...
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