Article
Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits.
PLoS genetics - 1 Mar 2011
Speliotes Elizabeth K, Yerges-Armstrong Laura M, Wu Jun, Hernaez Ruben, Kim Lauren J, Palmer Cameron D, Gudnason Vilmundur, Eiriksdottir Gudny, Garcia Melissa E, Launer Lenore J, Nalls Michael A, Clark Jeanne M, Mitchell Braxton D, Shuldiner Alan R, Butler Johannah L, Tomas Marta, Hoffmann Udo, Hwang Shih-Jen, Massaro Joseph M, O'Donnell Christopher J, Sahani Dushyant V, Salomaa Veikko, Schadt Eric E, Schwartz Stephen M, Siscovick David S, Voight Benjamin F, Carr J Jeffrey, Feitosa Mary F, Harris Tamara B, Fox Caroline S, Smith Albert V, Kao W H Linda, Hirschhorn Joel N, Borecki Ingrid B
Abstract excerpt
Nonalcoholic fatty liver disease (NAFLD) clusters in families, but the only known common genetic variants influencing risk are near PNPLA3. We sought to identify additional genetic variants influencing NAFLD using genome-wide association (GWA) analysis of computed tomography (CT) measured hepatic steatosis, a non-invasive measure of NAFLD, in large population based samples. Using variance components methods, we...
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