Article
Genetic determinants of susceptibility and severity in nonalcoholic fatty liver disease.
Expert review of gastroenterology & hepatology - 1 Apr 2011
Daly Ann K, Ballestri Stefano, Carulli Lucia, Loria Paola, Day Christopher P
Abstract excerpt
Nonalcoholic fatty liver disease (NAFLD) in most patients involves only simple hepatic steatosis; however, a minority develop progressive steatohepatitis. Family studies and inter-ethnic differences in susceptibility suggest that genetic factors may be important risk determinants for progressive disease. Polymorphisms in genes affecting lipid metabolism, cytokines, fibrotic mediators and oxidative stress may be...
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