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Article

A comprehensive evaluation of candidate genetic polymorphisms in a large histologically characterized MASLD cohort using a novel framework.

Hepatology communications - 1 Jun 2025

Hakim Aaron, Lin Kung-Hung, Schwantes-An Tae-Hwi, Abreu Marco, Tan Jingyi, Guo Xiuqing, Yates Katherine P, Lotta Luca, Verweij Niek, Loomba Rohit, Kleiner David E, Schwimmer Jeffrey B, Rotter Jerome I, Chalasani Naga P

Abstract excerpt

BACKGROUND: There is a substantial heritable component to metabolic dysfunction-associated steatotic liver disease (MASLD), and several genetic variants that promote MASLD development or associate with its severity have been reported. These associations vary in terms of their effect size and degree of replication. METHODS: We developed a framework to classify previously identified MASLD genetic polymorphisms into...

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Identifiers

PMID: 40434633
DOI: 10.1097/HC9.0000000000000728
PMCID: PMC12122170

Genes

PNPLA3
HSD17B13
PARVB
SAMM50
TM6SF2

Provenance

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A comprehensive evaluation of candidate genetic polymorphisms in a large histologically characterized MASLD cohort using a novel framework.PMID 40434633Read ↗

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