Article
Influence of Genetic Variations in miRNA and Genes Encoding Proteins in the miRNA Synthesis Complex on Toxicity of the Treatment of Pediatric B-Cell ALL in the Brazilian Amazon.
International journal of molecular sciences - 23 Feb 2023
da Silva Menezes Elisa, de Moraes Francisco Cezar Aquino, de Nazaré Cohen-Paes Amanda, Wanderley Alayde Vieira, Pereira Esdras Edgar Batista, Pastana Lucas Favacho, Modesto Antônio André Conde, de Assumpção Paulo Pimentel, Burbano Rommel Mario Rodríguez, Dos Santos Sidney Emanuel Batista, Dos Santos Ney Pereira Carneiro, Fernandes Marianne Rodrigues
Abstract excerpt
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer in the world. Single nucleotide variants (SNVs) in miRNA and genes encoding proteins of the miRNA synthesis complex (SC) may affect the processing of drugs used in the treatment of ALL, resulting in treatment-related toxicities (TRTs). We investigated the role of 25 SNVs in microRNA genes and genes encoding proteins of the miRNA SC, in 77...
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